Can fluid retention & pedal/dependent edema by caused by cyclobenzaprine or trazadone, or a combination of the 2? About 2 mos. ago I fell and injured my posterior shoulder and scapula. The pain didn't get better with Hi Dose NSAIDS tid x 6 weeks, and it was keeping me from sleeping at night. I saw my PCP about 2 1/2 weeks ago for the issue and she ordered cyclobenzaprine 10 mg bid and trazadone 50 mg qhs. I started taking both after filling the scripts that day and within 3-4 days noticed slight fluid retention in my hands/feet. It has gradually gotten worse and now is more moderate to severe than mild. My rings and shoes don't fit, my ankles have 2+ pitting edema, the edema goes up to my knee area in lessening degrees the higher up you go, when I get into a "squat" position, like for the weightlifting exercise of the same name- I can feel the the fluid in my knee joints displace from the change of position, and when standing up straight my knee joints "feel" like they are full of water. When I was 8-9 mos pregnant with my last baby at age 38 I experienced similar edema, but this episode is borderline more severe than that episode. The addition of these new medications is the only change from the "norm" I have made to my daily routine in the last month. There has been no change to my diet or activity level.