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Weight loss secondary to using Sertraline.

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Will losing weight around 15 pounds or so make Sertraline have a stronger affect? I know that losing weight frequently changes the affects that different medications have on the body. Just was wondering as I am going through a weight loss cycle (planned) and was wondering if it would affect Sertraline.

Thanks
Jason

Category: Family Physician-GP

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Dr. Jaydeep Tripathy
Category: HIV- AIDS Specialist
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 22 Doctors Online

Expert:  Dr. Jaydeep Tripathy
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Hello Jason,

Theoretically Yes, practically No.

15 pounds weight loss can slightly increase the drug distribution / body weight. But you will not see any changes because of this. Sertraline is a slow acting drug. It might take few weeks the drugs to take its full effect. Moreover the drug is eliminated via liver. So the elimination kinetics differ in individuals. It could actually vary even in individuals. So loss of 15 pounds is not concern at all.

Thank you

Dr. Jaydeep Tripathy
Category: HIV- AIDS Specialist
Experience: 
MBBS from Sri Ramachandra University in December 2011
M.Med (Family Medicine) - TNMGR University, Chennai
MBA-MPH in Public Health in March 2016, SRM University
Finished AFIH in March 2016, SRM University
MRCP ( UK ), Internal Medicine, Royal College of Physicians, June 2016
Fellowship in Diabetology from Martin Luther University in January 2017

Currently Resident Physician, in MD Radiodiagnosis - Kamakshi Memorial Hospital, Chennai
Dr. Jaydeep Tripathy and 4 other Medical Specialists are ready to help you

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