My question regards least intrusive , but possible effective treatment for chronic bacterial prostatitis.

Non traditional symptoms ( nausea, abdomen discomfort, fatigue…. but no enlargement, urinary issues at all) resulted in 6 months of misdiagnosis as GI Issues.

Two day thorough work up at Mayo Clinic resulted in diagnosis 3.0 years ago “Methicillin Resistant Staph Aureus Prostatitis”

Sensitivities cultures showed many IV antibiotics susceptible plus Bactrim and Minocycline. ( I noticed Quinolones did not appear on sensitivity test as I was noted as allergic to quinolones – which is not the case, it was an error in self reporting)

Over the next 2.5 years , the symptoms would go from very flush to feeling well within a week on Bactrim. Five 4-6 weeks courses were needed and then months of feeling fine.
It seemed that sexual activity without condom would “activate “ infection two weeks later?

Once again no BPH ( prostate regular dimensions, no urinary issues at all.) There would be nausea, a little prostate discomfort, projection of pain to front left ( about one inch to left of belly button and two down). Symtpoms worst upon waking. As soon as Bactrim taken all symptoms would go away

Tried minocycline once and it had pretty strong hypothyroid consequences. Primarily very irregular heart beat. I never tried to overcome with extra thyroid supplementation .

Recently Bactrim was bacteriostatic at best. Doesn't seem to work now to "kill" it off.

I once had to take Zithromax for “travelers diarrhea “ while in Europe and prostate symptoms got better. Made me wonder , do I necessarily have the same bug years later.

When I get it I am quite sick and tired, almost like having flu.

Recently when visiting with a local urologist he said it may be time for a “hail Mary “ pass , a TURP. In visiting with a friend who is a preventative medicine MD he thought that was early and a bit extreme
Recent careful gray and color Doppler ultrasound study reveals a normal size and configuration prostate for my age. There are multiple calcification, more towards the base. There are no abscesses or masses. There is inflammatory evidence at left mid to apex measuring 12 by 7mm which is the likely location of the infection. It does not appear around the calcification.

I am now on 250mg Levaquin for two weeks or four weeks …..?

Options

Being as I have no BPH , no urinary issues and localized infection along with a 3 year interval I wonder if there would not be options before a TURP.....which patients often report created new urinary and inflammatory issues along with a very painful process.

Specifically,
Could a procedure take prostatic fluid and or tissue for culture to identify offending bacterium.?
Could the offending bacterium then be finally eradicated with long term target use of an antibiotic
( it could be a wholly different organism then we have assumed)

In the alternative are their procedure short of a Hail Mary? ( a shorter pass perhaps That might "open" a channel to the infected area,or using laser to remove the area or TUNA or TUMT, or some other less intrusive technique than a turp which could create problems I don't have eg urinary issues.

if money is not an issue and it was you what alternative to identifying and addressing the specific location of the specific infection other than a TURP might you consider/

Any advice is greatly appreciated