Patient replied :
Do you believe that the bone scan works worse on mets for lobular cancer?
Yes. If there is evidence of bone destruction and the process of remodeling is going on !
Patient replied :
Did you mean to say that bone scan works badly for lobular cancer? I'm confused because you said yes, but the rest of your answer doesn't seem to fit with that--the rest of your answer sounds like you think it works fine for lobular.
Also, one more question: do you think that osteoblastic cancer will show up on a plain ct (with no pet)? I heard that there is cortical destruction around an osteoblastic cancer, that helps it show up on ct scans. Is it true that blastic cancers can cause cortical destruction?
I hope you read completely about the articles I sent you on PET and Bone Scan. These two radionuclide investigations have different mechanisms of interpreting the disease.
Bone scan will be positive in case of active bone remodelling taking place at the site of destruction by tumor mediated osteoclasts.
PET CT correlates with glucose uptake mechanisms in cancer cells. May act differently in lobular cancer. Hence chances of varied sensitivity and specificity in these scans.
Hope your doubt is cleared. I apologise if I was misunderstood.
Regards.