Hello,
Thank you for your query at DoctorSpring.com.

Yes apart from TMP/SMZ, there are other options available like Doxycycline or Carbenicillin.
Especially Doxycycline seems to work well in patients refractive to the conventional TMP-SMZ/ Fluoroquinolones therapy.

Chronic prostatitis is a recurring problem. Most of the patients shall be fine for 5-6 months and then have flare up and need to be treated with prolonged course of antibiotics.

You can try taking Doxycycline. You need to continue Doxycycline for a month Tab. 100 mg twice daily. Make sure you eat before the medicine and also take lactobacillus supplements. In some cases treatment up to 3 months is required. If Doxycycline does not work, then some other options that suppress the infection immediately are Nitrofurantoin, or Nalidixic acid. Even Cephalexin works well provided TMP-SMZ therapy and FQ therapy has not been very helpful. You can consult about this possible options with your physician and start accordingly.

Hope this helped, please free to follow-up,

Take care

Regards.