I am a 27 year old female.

Is vaginally applied Estrace (estradiol vaginal cream) supposed to be absorbed completely, and if so, how long does it generally take? I was recently prescribed 1g Estrace cream to be applied vaginally every 3 days, however, it seems that the majority remains in the vaginal canal and does not absorb completely or just works its way back out over the next 2 ~ 3 days.

I was prescribed the estrace cream approximately 13 months post vaginoplasty due to recurrent bleeding during penetrative intercourse. The vaginal canal upon examination, prior to being prescribed the cream, was observed to be fully healed with no signs of open lesion or otherwise, and thus my gynecologist felt that the use of the medication would assist in creating more elasticity of the vaginal wall, which they felt was liking tearing during penetrative intercourse.

My vaginal canal produces very minimal amounts of secretion / moisture and I always require lubrication during any form of vaginal insertion. The vaginoplasty was primarily created out of skin graft material, and thus is not like that of a "normal" vagina. I have no ovaries, uterus or cervix present and rely solely on medication based hormones.