Resolved question:
I am staying at Hong Kong and 32 years old. I do not have habits of alchahol/cigarrate consumption. In November I had two experiences of very very small tickle of blood from my left nose . In December first week again I had the same experience, this time slightly more but a trickle only.
I consulted one ENT. He checkd inside nose and told its fine and avoid spicy foods and blowing of nose and gave two medicines for allergies. Today morning when I woke up again I found very very small blood in my left nose. Nowadays, when I woke up I also feel very soar throats and it last for only 15-30 mins after that all normal.
Whether here nowadays is 10-15 degree compare to 30 degree other days of year. Humidity is varying between 30-80....
I am not using any sprays nowadays.....
My daughter and wife had also some bloods in nose last year. But this is first time in my life happening.
Can you help me in this regard. My ENT doctor also told me that if blood comes again then he will fix it with some vax inside my nose.
Submitted:
4 Days
Category:
Hepatologist
Hi,
Thanks for posting your query on DoctorSpring.com
Can you explain in detail what you wanted to know?
It would help me answer your query far better if I knew what you mean by the words 'long term' , 'overdose', and your specific medical history.
Well in 2001 i had no problems and had a negative AMA test. I was then given a double overdose of rifinah for seven and a half weeks 1200mg rifampicin per day and 600mg isoniazid per day. After this i was very weak and ill and i was left with hepatits that lasted 6 months and a positive AMA test since diagnosed as PBC. I have also had POTs syndrome and some other ilnesses come on shortly after. I have found numerous reports sugesting a link between these events and i am looking for some further information. Thank you.
Hello,
Thanks for providing the additional information.
AMA can be positive against many different antigens (For eg M1 M2 etc).
Isoniazid can cause liver injury and can also result in development of antimicrobial antibodies (AMA) against M6 antigen.
AMA against M2 is more specific for primary biliary cirrhosis.
You can get a liver biopsy done if not done already for further evaluation.
Let me know if I can assist you further.
So is it possible that the Isoniazid may have triggered pbc or that the drug induced hepatitis may have triggered it? AMA negative before overdose and positive after overdose.
Hi,
Are you AMA positive against M2 antigen or M6 antigen?
Regards.
It is the m2 antigen. The research i have done involving apoptosis, caspase 3 and oxidative stress seem to suggest a link is there. When you consider that a healthy man in his early 30s has developed pbc (a liver condition that mainly women get) just after an overdose of a liver damaging drug which induced chronic hepatitis. it seems that there would be a link there. thanks
Hi,
I would say it is a rare possibility or even unlikely for medications like INH to induce antibody against M2 antigen.
More research work is needed to look for this link.
I would advise you to get a liver biopsy done ( if not done already) to confirm the diagnosis of PBC.
Regards.